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目的:探讨单纯性肥胖儿童外周血obestatin、ghrelin、ghrelin/obestatin(G/O)比值水平变化及与胰岛素抵抗(IR)的关系。方法:选取单纯肥胖组50例,正常对照组30例,采用放免法(RIA)测定其血清obestatin、ghrelin,采用全自动荧光免疫分析系统测定空腹血清胰岛素(FINS),采用生化法测定空腹血糖(FBG)、血脂,并计算HOMA-IR值。结果:单纯性肥胖组血清obestatin、ghrelin水平明显低于对照组(P<0.05),G/O比值无明显差异(P>0.05),HOMA-IR、甘油三酯、总胆固醇、低密度脂蛋白均高于对照组(P<0.05)。线性偏相关分析obestatin与FINS、HOMA-IR负相关(P均<0.01),gh-relin与BMI、WHR、HDLC、HOMA-IR负相关(P均<0.05),G/O比值与WHR呈负相关(P<0.05)。结论:obestatin、gh-relin水平的降低可能参与了肥胖、胰岛素抵抗的发生,它们可能具有防止肥胖和IR的作用。
Objective: To investigate the changes of the levels of obestatin, ghrelin and ghrelin / obestatin (G / O) in obese children with simple obesity and their relationship with insulin resistance (IR). Methods: Fifty cases of simple obesity group and 30 cases of normal control group were selected. Serum obestatin and ghrelin were determined by radioimmunoassay (RIA) and fasting serum insulin (FINS) was determined by automatic fluorescence immunoassay. Fasting plasma glucose FBG), lipids, and calculate HOMA-IR values. Results: Serum levels of obestatin and ghrelin in simple obesity group were significantly lower than those in control group (P <0.05), and there was no significant difference in G / O ratio (P> 0.05). HOMA-IR, triglyceride, total cholesterol, low density lipoprotein All higher than the control group (P <0.05). Linear correlation analysis showed that there was a negative correlation between obestatin and FINS and HOMA-IR (all P <0.01), gh-relin was negatively correlated with BMI, WHR, HDLC and HOMA-IR Related (P <0.05). Conclusion: The decrease of obestatin and gh-relin levels may be involved in the development of obesity and insulin resistance. They may have the effect of preventing obesity and IR.