论文部分内容阅读
As both a sensor and a transducer, ATM- and Rad3-related (ATR) responds to a broad spectrum of DNA damages, including DNA double-strand breaks and many others that interfere with DNA replication, and also plays a crucial role in the suppression of telomere fragility and recombination[1-4]. It triggers a bunch of downstream genes and pathways. However, little is known about the regulatory mechanisms for ATR expression itself. MicroRNAs are a class of small non-coding RNAs critically functioning across various biological processes via post-transcriptionally regulating the expression of targeted genes in a sequence-specific manner.
As both a sensor and a transducer, ATM- and Rad3-related (ATR) responds to a broad spectrum of DNA damages, including DNA double-strand breaks and many others that interfere with DNA replication, and also plays a crucial role in the suppression Of telomere fragility and recombination [1-4]. It triggers a bunch of downstream genes and pathways. However, little is known about the regulatory mechanisms for ATR expression itself. MicroRNAs are a class of small non-coding RNAs critically functioning across various biological processes via post-transcriptionally regulating the expression of targeted genes in a sequence-specific manner.