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目的分析吡格列酮二甲双胍治疗肥胖型多囊卵巢综合征的疗效及对胰岛素敏感性和排卵的影响。方法选取2014年4月~2015年4月该院收治的88例多囊卵巢综合征患者为研究对象,以治疗方法为分组依据进行分组,服用二甲双胍治疗的患者设为对照组(44例),服用吡格列酮二甲双胍治疗的患者设为观察组(44例)。对两组患者用药前后激素水平的改变情况、排卵和妊娠情况以及临床症状改善情况进行对比分析。结果观察组患者胰岛素敏感指数(ISI)、卵泡刺激素(FSH)、黄体生成素(LH)以及睾酮(T)分别为(-2.65±0.82)、(6.88±2.25)、(5.34±1.43)和(2.53±0.83)m IU/L,对照组患者的ISI、FSH、LH以及T分别为(-3.45±1.73)、(7.34±2.42)、(7.93±2.82)和(3.54±1.53)m IU/L,两组比较,差异均有统计学意义(P<0.05);观察组总有效率(93.18%)与对照组总有效率(68.18%)相比相对较高,差异有统计学意义(P<0.05);观察组患者排卵率、妊娠率、成熟卵泡数及促排卵天数与对照组患者比较,差异均有统计学意义(P<0.05)。结论吡格列酮二甲双胍治疗肥胖型多囊卵巢综合征的临床作用更为突出,提高了临床治疗效果,有效地改善了激素水平,提高了胰岛素的敏感性,同时促进排卵,在临床上应用具有重要意义。
Objective To analyze the effect of pioglitazone and metformin on the treatment of obese patients with polycystic ovary syndrome and its effect on insulin sensitivity and ovulation. Methods From April 2014 to April 2015, 88 patients with PCOS admitted to the hospital were enrolled in this study. The patients were divided into groups according to the treatment methods. The patients treated with metformin were selected as the control group (44 cases) Patients treated with pioglitazone metformin were assigned to the observation group (n = 44). The change of hormone level, the condition of ovulation and pregnancy and the improvement of clinical symptoms before and after treatment were compared between the two groups. Results The ISI, FSH, LH and testosterone were (-2.65 ± 0.82), (6.88 ± 2.25) and (5.34 ± 1.43) and (2.53 ± 0.83) mIU / L, and the ISI, FSH, LH and T in the control group were (-3.45 ± 1.73), (7.34 ± 2.42), (7.93 ± 2.82) and (3.54 ± 1.53) mIU / (P <0.05). The total effective rate (93.18%) in the observation group was higher than that in the control group (68.18%), the difference was statistically significant (P <0.05). The ovulation rate, pregnancy rate, number of mature follicles and days of ovulation induction in observation group were significantly different from those in control group (P <0.05). Conclusion The clinical effect of pioglitazone and metformin in the treatment of obese patients with polycystic ovary syndrome is more prominent, which improves the clinical therapeutic effect, effectively improves the hormone level, increases the insulin sensitivity and promotes the ovulation. It is of great significance in clinical application.