皮内接种与肌肉接种相比,可降低注射剂量50～90%,而免疫应答无明显减弱。作者对18名健康青年志愿者(平均年龄26岁)进行皮内(9人)或肌肉(9人)注射单剂同一批号疫苗,疫苗为0.2%氢氧化铝溶液0.5ml,内含0.35μg甲醛灭活蜱传脑炎病毒(TBEV)。A组于0和28天在两前臂掌侧和两小腿跖侧分别皮内注射1/4剂量,而B组在三角肌注射单剂疫苗。在0、7、10、14、21、 Inoculation compared with intramuscular inoculation, can reduce the injection dose of 50 to 90%, while the immune response was not significantly reduced. The authors injected 18 healthy young volunteers (mean age 26 years) with a single dose of the same batch of vaccine (9 persons) or muscle (9 persons) in a dose of 0.5 ml 0.2% aluminum hydroxide solution containing 0.35 μg formaldehyde Inactivated tick-borne encephalitis virus (TBEV). In Group A, ¼ dose was injected intradermally on the palmar side of both forearms and plantar side of both lower wrists on Days 0 and 28, while Group B was given a single dose of vaccine in the deltoid muscle. At 0, 7, 10, 14, 21,