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目的观察氟伐他汀及阿司匹林对急性冠状动脉综合征患者高敏C反应蛋白(hs-CRP)及血脂的影响。方法选取2006年7月至2008年10月在我科住院的冠状动脉粥样硬化性心脏病(简称:冠心病)患者共计90例,随机分为3组,A组为氟伐他汀组,给予氟伐他汀40mg/d;B组为阿司匹林组,给予阿司匹林300mg/d;C组为联合用药组,给予氟伐他汀及阿司匹林联用;选取30例健康对照组为D组。药物治疗连续8周。治疗前后检测血中hs-CRP及三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果ABC三组患者治疗后hs-CRP与治疗前相比下降(P<0.05),与AB组比较C组hs-CRP下降更为明显(P<0.05),但仍高于对照组(P<0.05);AC两组患者治疗后TG、TC、LDL-C下降(P<0.05);ABC三组hs-CRP水平的降低与TG、TG、LDL-C水平的降低无明显相关性(P>0.05)。结论氟伐他汀可有效降低冠心病患者的TG、TC、LDL-C;氟伐他汀及阿司匹林均能降低冠心病患者的hs-CRP水平,两种药物联用降低更为明显。
Objective To observe the effect of fluvastatin and aspirin on high-sensitivity C-reactive protein (hs-CRP) and serum lipids in patients with acute coronary syndrome. Methods A total of 90 patients with coronary atherosclerotic heart disease (referred to as coronary heart disease) hospitalized in our department from July 2006 to October 2008 were randomly divided into 3 groups, group A was treated with fluvastatin, Fluvastatin 40mg / d; B group aspirin group given aspirin 300mg / d; C group was combined with fluvastatin and aspirin given; combination group of 30 healthy controls for the D group. Drug treatment for 8 weeks. Blood hs-CRP, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured before and after treatment. Results The hs-CRP in ABC group decreased significantly compared with that before treatment (P <0.05), but the hs-CRP decreased more significantly in C group than that in AB group (P <0.05), but still higher than that in control group (P < (P <0.05). The levels of TG, TC and LDL-C in two AC groups decreased after treatment (P <0.05). The reduction of hs-CRP in ABC three groups had no significant correlation with the decrease of TG, TG and LDL- 0.05). Conclusions Fluvastatin can effectively reduce TG, TC and LDL-C in patients with coronary heart disease. Both fluvastatin and aspirin can reduce hs-CRP in patients with coronary heart disease, and the combination of the two drugs is more obvious.