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目的了解药品不良反应(adverse drug reactions,ADR)报告中超说明书用药的情况,为临床合理用药提供参考。方法对2014年1~12月收集的药品不良反应报告共700例进行回顾性分析,根据药品说明书对超说明书用药情况进行分析。结果 700例ADR报告中,共有医嘱1 605条,有267份超说明书用药报告(38.1%),有416条超说明书医嘱(25.9%),类型主要为超给药频次、超给药剂量和超适应症,超说明书用药构成比居前3位的药物依次为银杏达莫注射液、前列地尔注射液和注射用美洛西林钠。结论 ADR报告中超说明书用药情况普遍存在,需加强监管,促进临床合理用药,减少ADR的发生。
Objective To understand the situation of drug abuse in the report of adverse drug reactions (ADR) and to provide a reference for clinical rational drug use. Methods A retrospective analysis was conducted on 700 cases of adverse drug reaction reports collected from January to December 2014. Drug consumption was analyzed according to the instruction manual. Results Of the 700 ADR cases, there were 1 605 medical orders, 267 reports of super-instructions (38.1%), 416 super-instructions (25.9%), and the main types were super-administration frequency, super-administration dose and ultra- Indications, super instructions drug composition than the top three drugs followed by gingko Damo injection, alprostadil injection and injection with mezlocillin sodium. Conclusion ADR report super manual instructions prevalence of the need to strengthen supervision, promote clinical rational use of drugs, reduce the occurrence of ADR.