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在卵巢癌肿瘤中经常能筛选到20q1213的放大,表明在此区域中至少存在一个重要的原癌基因。其中EEF1A2位于20q13.3,编码蛋白质延长因子eEF1A2。该文主要就EEF1A2是一个重要的卵巢原癌基因及蛋白延长因子网络能激活肿瘤发生并抑制凋亡作一综述。
In ovarian cancer tumors, amplification of 20q1213 can often be screened, indicating that there is at least one important oncogene in this region. EEF1A2 is located in 20q13.3, encoding protein elongation factor eEF1A2. This review summarizes that EEF1A2 is an important ovarian proto-oncogene and protein elongation factor network that can activate tumorigenesis and inhibit apoptosis.