论文部分内容阅读
目的:探讨海马硬化和难治性颞叶癫的因果关系。方法:对8例海马硬化患者和7例非海马硬化患者临床资料、手术疗效和海马病理改变进行对比和相关分析。结果:海马硬化组较非海马硬化组病程长,疗效显著,疗效分级与最初脑损伤发生年龄呈正相关。海马硬化组和非海马硬化组均有CA1,CA3锥体细胞和颗粒细胞脱失,海马硬化组更明显。门区神经元脱失仅在海马硬化组可见。海马神经元脱失与脑损伤发生年龄呈正相关。结论:生命早期的脑损害是海马硬化的成因。硬化海马是难治性癫的致灶。以海马结构齿状回门区神经元,颗粒细胞和海马CA3锥体细胞脱失为特点的海马硬化是难治性颞叶癫的主要病理特点和病因,门区细胞的脱失是海马硬化的特征性病理改变,可能在难治性癫的发病机理中起着重要作用。
Objective: To explore the causal relationship between hippocampal sclerosis and refractory temporal lobe epilepsy. Methods: The clinical data of 8 cases of hippocampal sclerosis and 7 cases of non-hippocampal sclerosis were compared and the correlation between the curative effect and pathological changes of hippocampus was analyzed. Results: Compared with the non-hippocampal sclerosis group, the hippocampal sclerosis group had a longer course of disease and the curative effect was significant. The grade of the curative effect was positively correlated with the age of initial brain injury. Hippocampal sclerosis group and non-hippocampal sclerosis group were CA1, CA3 pyramidal cells and granulosa cells, hippocampal sclerosis group more obvious. Deletion of neurons in the portal zone was only visible in the hippocampal sclerosis group. Hippocampal neuron loss and brain damage occurred at a positive correlation. Conclusion: Early life brain damage is the cause of hippocampal sclerosis. Hardened hippocampus is refractory epilepsy induced. The hippocampal sclerosis characterized by degeneration of neurons, granulosa cells and hippocampal CA3 pyramidal neurons in the dentate gyrus of hippocampus is the main pathological characteristic and etiology of refractory temporal lobe epilepsy. Characteristic pathological changes, may play an important role in the pathogenesis of refractory epilepsy.