老年性骨质疏松症已经成为常见的老年性疾病。骨代谢包括骨形成与骨吸收,两者要维持一个动态平衡。胰岛素样生长因子在骨形成中起重要作用．胰岛素样生长因子的降低是骨代谢老龄化的重要原因．在骨吸收过程中,破骨细胞起关键作用．骨保护素是调节骨吸收的主要因子,通过与细胞核因子kappaB受体活化因子的配体结合,抑制其对破骨细胞信号转导的活化．目前研究认为众多激素、生长因子和细胞因子包括胰岛素样生长因子最终参与调节骨保护素／κB受体活化因子／κB受体活化因子的配体系统,均衡两类细胞的数量和活性,影响骨代谢平衡． Senile osteoporosis has become a common senile disease. Bone metabolism includes bone formation and bone resorption, both to maintain a dynamic balance. Insulin-like growth factor plays an important role in bone formation. Reduction of insulin-like growth factor is an important reason for the aging of bone metabolism. Osteoclasts play a key role in bone resorption. Osteoprotegerin, a major regulator of bone resorption, inhibits its activation of osteoclast signaling by binding to the ligand of the kappaB receptor activator of the nuclear factor kappaB. Current research suggests that many hormones, growth factors and cytokines, including insulin-like growth factor, eventually participate in the regulation of the ligand system of the osteoprotegerin / κB receptor activator / κB receptor activator, balancing the quantity and activity of both types of cells, Metabolic balance.