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目的观察格列美脲与质子泵抑制剂对2型糖尿病的疗效。方法选取医院收治的2型糖尿病患者120例为研究对象,随机分为对照组和观察组,每组60例。对照组采用质子泵抑制剂奥美拉唑肠溶片治疗,观察组在对照组的基础上采用格列美脲治疗。观察比较2组治疗前后依次测定BMI、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2h PBG)、2 hIns、FIns及不良反应。结果治疗后,FBG,2 hPBG,HbA1c均优于治疗前(P<0.05);但观察组治疗效果优于对照组(P<0.05);而治疗前后,2组均在FIns、2 hIns、BMI等指标方面无明显差异(P>0.05)。在随访期间,2组均未发生低血糖事件、水肿及心血管疾病等并发症。结论格列美脲与质子泵抑制剂对2型糖尿病有良好的临床疗效,不仅可降低血糖,还可改善血管功能,且有安全性,值得临床推广应用。
Objective To observe the effect of glimepiride and proton pump inhibitors on type 2 diabetes mellitus. Methods A total of 120 type 2 diabetic patients admitted to the hospital were selected as study subjects and randomly divided into control group and observation group with 60 cases in each group. The control group was treated with omeprazole enteric-coated proton pump inhibitor. The observation group was treated with glimepiride on the basis of the control group. The levels of BMI, HbA1c, fasting blood glucose (FBG), 2h PBG, 2hIns, FIns and adverse reactions were observed and compared before and after treatment. Results After treatment, FBG, 2 hPBG and HbA1c were better than those before treatment (P <0.05), but the observation group was better than the control group (P <0.05) No significant difference in other indicators (P> 0.05). During follow-up, no complications such as hypoglycaemia, edema and cardiovascular disease occurred in both groups. Conclusion Glimepiride and proton pump inhibitors have a good clinical effect on type 2 diabetes mellitus, not only can reduce blood sugar, but also improve vascular function, and have safety, worthy of clinical promotion and application.