报告３１例结直肠癌用ｃ－ｅｒｂＢ－２／ｎｅｕ单克隆抗体作免疫组织化学染色，阳性率高达９３．５％，其中强用性６１．３％（１９／３１）。呈强阳性的１９例中，５年内死亡４７．４％（９／１９），中位数（Ｍ）生存期仅２４个月，而呈阴性的２例分别于术后５年半和６年半仍健在。结合长期随访分析，ｃ－ｅｒｂＢ－２／ｎｅｕ基因表达的水平与病者术后生存期有明显的负相关，可以作为推测结直肠癌病者预后的指标。 31 cases of colorectal cancer were reported with immunohistochemical staining with c-erbB-2/neu monoclonal antibody. The positive rate was as high as 93.5%, of which 61.3% (19/31) was strong. Of the 19 cases that were strongly positive, 47.4% (9/19) died within 5 years, the median (M) survival period was only 24 months, and the negative cases were 5 years and 5 years and 6 years after surgery. Half still alive. Combined with long-term follow-up analysis, the level of c-erbB-2/neu gene expression was significantly negatively correlated with the patient’s postoperative survival, and could be used as an indicator of prognosis of colorectal cancer patients.