卵巢是重要的生殖内分泌器官,随着人类寿命的明显延长和婚育年龄的推迟,如何延长卵巢寿命和保护卵巢功能是人们越来越关注的问题。沉默信息调节因子Sir 2在哺乳类动物中有7个同源基因,其中与酵母菌Sir 2相似度最高的就是SIRT 1。依赖NAD+的组蛋白去乙酰化酶SIRT 1在调节细胞的代谢、分化与衰老等方面都有着关键的影响与作用[1],并且近年也成为越来越多人研究的热点。 Ovary is an important reproductive and endocrine organ. With the significant extension of human life expectancy and postponement of marriage and childbearing age, how to prolong ovarian lifespan and protect ovary function is an issue that people pay more and more attention to. Sir2, a silent information regulator, has 7 homologous genes in mammals, of which SIRT1 is most similar to yeast Sir2. SIRT1, a NAD + -dependent histone deacetylase, plays a key role in the regulation of cell metabolism, differentiation and aging [1], and has also become a hot spot in more and more people in recent years.