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目的 :探讨虹膜角膜内皮 (ICE)综合征的发病机制。方法 :对 8例 ( 1 0只眼 )ICE综合征患者的临床表现、分型及治疗效果进行分析和数据统计。并介绍目前国内外一些新的研究进展。结果 :8例ICE综合征患者临床表现为三型 :原发性进行性虹膜萎缩 7只眼 ,Chandler氏综合征 1只眼 ,Cogan Reese综合征 2只眼。 1 0只眼均继发闭角型青光眼 ,2只眼并发大泡性角膜病变。 9只眼行一次或多次滤过手术 ,1只眼行角膜移植术。结论 :ICE综合征的基本病变是角膜内皮层存在的ICE细胞 ,它们的过度增生导致房角粘连、虹膜萎缩、继发性青光眼和大泡性角膜病变。目前滤过手术及角膜移植术只能在一定程度上缓解眼压及改善角膜质量 ,但不能根本有效地阻止ICE细胞的扩散。
Objective: To investigate the pathogenesis of iris corneal endothelial (ICE) syndrome. Methods: Eight patients (10 eyes) ICE syndrome, clinical manifestations, classification and treatment effect analysis and statistics. And introduce some new research progress at home and abroad at present. Results: The clinical manifestations of 8 ICE patients were three types: primary progressive iris atrophy in 7 eyes, Chandler’s syndrome in 1 eye and Cogan Reese syndrome in 2 eyes. 10 eyes were secondary to closed-angle glaucoma, 2 eyes complicated by bullous keratopathy. Nine eyes underwent one or more filtration surgeries and one corneal transplant. CONCLUSIONS: The underlying pathology of ICE syndrome is the presence of ICE cells in the corneal endothelium, hyperproliferation of which leads to corner adhesion, iris atrophy, secondary glaucoma and bullous keratopathy. At present, filtration surgery and corneal transplantation can only relieve intraocular pressure and improve corneal quality to some extent, but can not fundamentally prevent the proliferation of ICE cells.