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近期的研究发现,从1996年至2011年,新药临床研发成功率逐年下降,2008—2011年3年平均成功率为7.5%,尚不到1996—1999年3年平均成功率(16.4%)的一半。2011年后数据开始反弹,2012—2014年3年平均成功率达11.6%。虽然这些年间小分子药物研发成功率下降幅度仍然巨大(从16%降至5%),生物大分子研发成功率则相对平稳。另一个值
Recent studies have found that the success rate of new drug clinical research and development fell from 1996 to 2011 with an average success rate of 7.5% for the three years from 2008 to 2011 and less than the 3-year average success rate (16.4%) for 1996-1999 half. After 2011 data began to rebound, 2012-2014 three-year average success rate of 11.6%. Although the success rate of research and development of small molecule drugs has dropped by a large margin (from 16% to 5%) in recent years, the success rate of research and development of biological macromolecules has been relatively stable. Another value