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目的提高联苯苄唑乳膏的质量。方法通过调整联苯苄唑乳膏的基质组成,改变主药联苯苄唑的加入方法制备联苯苄唑乳膏;并对改进处方与原处方制剂进行1年的保留样观察试验。结果改进处方制备的联苯苄唑乳膏更细腻,无砂粒感,放置无变硬、变干现象,稳定性明显优于原法制备的乳膏。结论改进的联苯苄唑乳膏处方合理、制备工艺简单可行,质量稳定可控。
Objective To improve the quality of bifonazole cream. Methods Bifonazole cream was prepared by adjusting the matrix composition of bifonazole cream and changing the addition method of bifonazole as the main drug. The modified prescription and the original formulation were reserved for one year. Results The bifonazole cream prepared by the improved prescription was more delicate, without gritty feeling, and had no harden and dryness when placed. The stability of the bifonazole cream was obviously better than the cream prepared by the original method. Conclusion The improved bifonazole cream prescription is reasonable, the preparation process is simple and feasible, the quality is stable and controllable.