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目的 :验证HMG CoA还原酶抑制剂辛伐他汀的降血脂作用。方法 :用含 3 %胆固醇饲料饲喂家兔 ,造成高脂血症模型。考察灌胃给药对血脂的影响。结果 :口服辛伐他汀可剂量依赖性地抑制血清总胆固醇 (TC)、甘油三酯(TG)的升高 ,对TC作用显著 ,TG有轻微降低 ,对高密度脂蛋白 (HDL C)有升高趋势 ,肝脏TC亦显著降低。降血脂作用与等剂量阳性对照药舒降之比较差异不显著。结论 :国产辛伐他汀对血脂升高具有预防作用。
Objective: To verify the hypolipidemic effect of simvastatin, an HMG CoA reductase inhibitor. Methods: Rabbits fed 3% cholesterol diet resulted in hyperlipidemia model. To examine the effects of intragastric administration on blood lipids. Results: Simvastatin orally inhibited the increase of total cholesterol (TC) and triglyceride (TG) in a dose-dependent manner, with a significant effect on TC, a slight decrease of TG and a rise of high density lipoprotein (HDL C) High trend, liver TC also significantly reduced. There was no significant difference between the hypolipidemic effect and the equivalent dose of the positive control drug. Conclusion: Domestic simvastatin can prevent hyperlipidemia.