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肿瘤靶向基因治疗的主要目的是用靶向性的载体将治疗基因靶向传递到肿瘤细胞。本文综述了3类用于肿瘤靶向基因治疗载体的肿瘤特异性配体:天然分子、单克隆抗体和靶向性多肽,以及由它们修饰的载体系统用于靶向性肿瘤基因治疗的研究进展。
The main purpose of tumor-targeted gene therapy is to deliver therapeutic gene targets to tumor cells with a targeting vector. This article reviews the progress of three types of tumor-specific ligands for tumor-targeted gene therapy vectors: natural molecules, monoclonal antibodies and targeting peptides, as well as vector systems modified by them for targeted oncology gene therapy .