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自噬是真核细胞消除异常蛋白质、维持自身稳态的主要代谢机制,负责大多数长寿命蛋白质和细胞器的清除。目前研究[1]发现肿瘤、神经退行性疾病、感染性疾病以及化学毒物如百草枯、甲基苯丙胺等引起的机体损伤都与自噬异常有关。在生理条件下,细胞自噬活性受哺乳动物雷帕霉素靶蛋白(mammal target of rapamycin,m TOR)、磷脂酰肌醇三磷酸激酶(phosphatidylinositol 3-kinase,PI3K)等上游信号调控,
Autophagy is the main metabolic mechanism that eukaryotic cells eliminate abnormal proteins and maintain their homeostasis, responsible for the removal of most of the long-lived proteins and organelles. The current study [1] found that tumors, neurodegenerative diseases, infectious diseases and chemical poisoning such as paraquat, methamphetamine and other body damage caused by autophagy are related to abnormalities. Under physiological conditions, autophagic activity is regulated by upstream signals of mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K)