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目的探讨充血性心力衰竭患者血清B型利钠肽(BNP)与左室大小的相关性。方法选择48例充血性心衰患者作为心衰组,选择同期25例健康体检者为对照组,用酶联免疫吸附法(ELISA)方法分别测定心衰组及健康对照组血清BNP水平,并行心脏超声检测左室射血分数(LVEF)、左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)及左室舒张末内径(LVEDd)。观察BNP与LVEF、LVEDV、LVESV及LVEDd的变化。结果①与对照组比较,心衰组血清BNP水平显著升高,且随着心功能分级程度的加重而增高,BNP与LVEF呈负相关,具有统计学意义(P<0.05);②BNP与LVEDV、LVESV、LVEDd呈正相关,有统计学意义(P<0.05)。结论心衰患者血清BNP水平的增加与LVEF下降及LVEDV、LVESV、LVEDd的增加有关,BNP可以作为心力衰竭严重程度的一个指标,也可能与左室大小有关。
Objective To investigate the relationship between serum B-type natriuretic peptide (BNP) and left ventricular size in patients with congestive heart failure. Methods Forty-eight patients with congestive heart failure were selected as the heart failure group. 25 healthy subjects were selected as the control group. Serum BNP levels were measured by enzyme-linked immunosorbent assay (ELISA) in the heart failure group and the healthy control group. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV) and left ventricular end diastolic diameter (LVEDd) were detected by ultrasound. The changes of BNP, LVEF, LVEDV, LVESV and LVEDd were observed. Results ①Compared with the control group, serum BNP level increased significantly in patients with heart failure, and increased with the degree of heart function grading. There was a negative correlation between BNP and LVEF (P <0.05); ② BNP and LVEDV, LVESV, LVEDd was positively correlated, with statistical significance (P <0.05). Conclusions The increase of serum BNP level in patients with heart failure is associated with the decrease of LVEF and the increase of LVEDV, LVESV and LVEDd. BNP can be used as an index of the severity of heart failure and may also be related to the size of left ventricle.