用聚合酶链反应（ＰＣＲ）方法动态观来了α－干扰素治疗的６例慢性乙型病毒性肝炎患者外周血单个核细胞（ＰＢＭＣ）与血清中乙型肝炎病毒（ＨＢＶ）ＤＮＡ的清除情况。血清ＨＢＶＤＮＡ在治疗５周后（３－１０周）６例转阴，其中２例在结束治疗时复转阳性，ＰＢＭＣ中ＨＢＶＤＮＡ在治疗１５周（１２－２０周）时５例转阴，１例始终阳性，并出现ＡＬＴ复升高。结果显示α－干扰素能清除ＰＢＭＣ中ＨＢＶＤＮＡ，但滞后于血清病毒的清除，ＰＢＭＣ中ＨＢＶＤＮＡ持续阳性，可能使治疗中期效果较差。 The clearance of peripheral blood mononuclear cells (PBMCs) and serum HBV DNA from 6 patients with chronic hepatitis B virus treated with α-interferon was dynamically observed by the polymerase chain reaction (PCR) method . Serum HBVDNA was negative in 6 cases after 5 weeks (3-10 weeks) of treatment, and 2 of them returned to positive at the end of treatment. HBVDNA in PBMC was negative in 5 cases at 15 weeks (12-20 weeks) and in 1 case Always positive, and ALT complex increased. The results showed that interferon-alpha cleared HBVDNA in PBMC but lagged the clearance of serum virus, and persistent positive HBVDNA in PBMC may make the treatment less effective in the mid-term.