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众所周知,氨基葡萄糖类抗生素对内耳损伤,主要是通过代谢废物使前庭和耳蜗发生中毒反应。本文采用20只小自鼠,分为二组,每组10只,每天分别腹膜内注射卡那霉素75mg/kg,10天和20天。对照组为8只,腹膜内注射生理盐水。10天组在内耳出现不同程度的内外毛细胞损伤,基底转最为明显。20天组在同样部位亦有损伤,但不如10天组明显。对照组正常。电镜下可见内毛细胞破坏或消失,耳蜗第一排外毛细胞也有同样变化。在损伤毛细胞中,感觉细胞角质板出现紊乱,细胞体及核肿胀,静纤毛融合,支持细胞亦肿胀或萎缩,血管纹水肿。前庭部分也有损伤,感觉细胞表面
As we all know, glucosamine antibiotics damage to the inner ear, mainly through metabolic waste poisoning the vestibule and cochlea. In this paper, 20 small mice, divided into two groups of 10, each intraperitoneal injection of kanamycin 75mg / kg, 10 days and 20 days. The control group of 8, intraperitoneal injection of saline. 10 days group appeared different degrees of inner and outer hair cells in the inner ear, basal turn the most obvious. The 20-day group was also damaged in the same site, but not as obvious as the 10-day group. The control group was normal. Electron microscope shows the destruction or disappearance of inner hair cells, outer hair cells in the first row of the cochlea also have the same changes. In the damage of hair cells, the sensory cells appear keratinocyte disorders, cell body and nuclear swelling, static cilia fusion, supporting cells also swollen or atrophied, vascular pattern edema. Vestibular parts are also damaged, feeling the cell surface