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目的探讨高密度脂蛋白(HDL)、甘油三酯(TG)、总胆固醇(TC)水平变化与老年原发性高血压患者预后的关系。方法选取2011年5月-2012年4月本院收治老年原发性高血压患者220例,随访3年,依据HDL、TG、TC水平分组,比较随访前后HDL、TG、TC水平变化,颈动脉厚度(IMT)、心电图,多因素Logistic回归分析HDL、TG/TC与预后关系。结果 3年后2组HDL水平均显著低于3年前,差异有统计学意义(P<0.05)。3年后HDL减低组HDL、SDNN水平低于HDL正常组,IMT高于HDL正常组,差异均有统计学意义(P<0.05)。3年后HDL减低组SDNN低于3年前,而IMT高于3年前,差异均有统计学意义(P<0.05)。多因素回归分析发现,血清HDL低水平、TG/TC高水平为原发性高血压患者心血管疾病预后危险因素。结论 HDL低水平、TG/TC高水平为原发性高血压患者心血管疾病危险因素。
Objective To investigate the relationship between the changes of high density lipoprotein (HDL), triglyceride (TG) and total cholesterol (TC) and the prognosis of elderly patients with essential hypertension. Methods From May 2011 to April 2012, 220 patients with senile essential hypertension in our hospital were followed up for 3 years. HDL, TG and TC were divided into groups according to HDL, TG and TC levels before and after follow-up. Carotid artery Thickness (IMT), electrocardiogram, multivariate Logistic regression analysis of HDL, TG / TC and prognosis. Results After 3 years, the levels of HDL in both groups were significantly lower than those of 3 years ago, the difference was statistically significant (P <0.05). The levels of HDL and SDNN in HDL reduction group after 3 years were lower than those in HDL normal group and IMT was higher than that in HDL normal group (P <0.05). After 3 years, the SDNN in HDL reduction group was lower than 3 years ago, while the IMT was higher than that in 3 years ago (P <0.05). Multivariate regression analysis found that low serum HDL levels and high TG / TC levels were risk factors for cardiovascular disease prognosis in patients with essential hypertension. Conclusions HDL low level and high TG / TC level are the risk factors of cardiovascular disease in patients with essential hypertension.