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目的:探讨不同部位症状性Rathke’s囊肿(RCC)手术方式的选择及临床疗效。方法:选择广东三九脑科医院神经外科自2016年1月至2019年12月和手术治疗的47例症状性RCC患者进入研究，其中21例单纯鞍内型患者行右侧单鼻孔入路，19例鞍内-鞍上型患者行双侧鼻孔入路，3例鞍上型患者采用内镜扩大经鼻蝶入路，4例单纯鞍上型患者采用开颅经翼点入路。比较不同手术方式治疗患者疗效及并发症发生情况。所有患者随访3~36个月，观察复发情况。结果:患者术后症状得到有效改善，其中头痛缓解比例为27/31，视力下降改善比例为5/5，高泌乳素缓解比例为11/13，垂体功能改善比例为9/18；共6例患者出现并发症，均表现为尿崩。随访期间4例患者出现复发。结论:鞍内型及鞍内-鞍上型RCC经鼻蝶入路行内镜治疗安全有效，单纯鞍上型RCC应根据囊肿体积及生长方向选择手术方式。“,”Objective:To explore the selection of surgical methods for different sites of symptomatic Rathke’s cleft cyst (RCC) and the clinical efficacies of these patients.Methods:Forty-seven patients with symptomatic RCC, admitted to our hospital from January 2016 to December 2019, were chosen in our study; 21 patients with intrasellar symptomatic RCC accepted surgery via unilateral nasal approach at the right side, 19 patients with intra-suprasellar symptomatic RCC accepted surgery via bilateral nasal approach, 3 patients with suprasellar symptomatic RCC accepted endonasal transsphenoidal surgery under endoscope, and 4 patients with suprasellar symptomatic RCC accepted craniotomy via pterion approach. The clinical efficacies and complications of patients accepted different surgical methods were compared. All patients were followed up for 3-36 months to observe the recurrence.Results:The postoperative symptoms of the patients were effectively improved, including headache relief ratio of 27/31, vision loss improvement ratio of 5/5, high prolactin relief ratio of 11/13, pituitary function improvement ratio of 9/18. Complications occurred in 6 patients, presenting as diabetes insipidus. Four patients recurred during follow-up.Conclusion:Intrasellar and intra-suprasellar symptomatic RCC accepted surgery via endoscopic transnasal transsphenoidal approach are safe and effective; selection of surgical methods for suprasellar symptomatic RCC should be determined according to the sizes and growth directions of cysts.