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大黄水提物和醇提物对小鼠离体肝脏体外培养过氧化脂质（ＬＰＯ）生成均有明显的抑制作用；大黄水提物可明显抑制阿霉素肝损伤和Ｄ－半乳糖亚急性衰老模型小鼠肝脏ＬＰＯ的升高。
Rhubarb aqueous extracts and alcohol extracts all significantly inhibited the production of lipid peroxide (LPO) in cultured mouse liver in vitro; Rhubarb aqueous extract significantly inhibited the liver injury of doxorubicin and D-galactose subacute Increased liver LPO in aging mice.