胆汁酸是胆汁中一大类胆烷酸的总称,通过与相关受体及胆汁酸转运蛋白结合,发挥其独特的生理功能.人体内胆汁酸除促进营养物质的吸收外,还作为重要的信号分子调节炎症过程、肝脏再生,并且越来越多的研究结果提示胆汁酸代谢参与慢性非胆汁淤积性肝病发生、发展的重要环节.该文在介绍上述最新研究成果的同时,重点阐述了胆汁酸代谢过程中发挥关键作用的核受体、膜受体及胆汁酸转运蛋白与慢性非胆汁淤积性肝病的关系.“,”Bile acid is a general term for a large class of cholic acid in bile and exerts its unique physiological functions by binding the relevant receptors and bile acid transporters.Bile acids not only promote the absorption of nutrients in the human body,but also as an important signaling molecule in the regulation of inflammatory processes and liver regeneration.Several studies have found that bile acid metabolism is involved in the occurrence and development of chronic non-cholestatic liver diseases.In this article,the latest research results are mentioned,and the relationship between nuclear receptors,membrane receptors,and bile acid transporters and chronic non-cholestatic liver disease that play a key role in the bile acid metabolism were emphatically reviewed.