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目的探讨妊娠期肝内胆汁淤积症(ICP)与新生儿出生体重的关系及临床意义。方法选取2012年5月-2015年5月在该院住院的150例ICP患者为研究对象,根据患者的诊断孕周分为两组,其中32周前确诊的患者为早发型组(A组),32周后确诊的患者为晚发型组(B组)。回顾性对比分析两组患者年龄,诊断孕周、分娩孕周,诊断至分娩间期,新生儿体重、肝酶和凝血指标的差异。结果两组诊断至分娩间期以及新生儿出生体重比较,差异有统计学意义(P<0.05),而两组年龄、分娩孕周、肝酶和凝血指标比较,差异无统计学意义(P>0.05)。相同的分娩孕周,早发型ICP孕妇分娩新生儿的体重低于晚发型ICP孕妇分娩的新生儿。结论 32周前确诊的早发型ICP与新生儿出生低体重相关。
Objective To investigate the relationship between clinical intrahepatic cholestasis of pregnancy (ICP) and birth weight and its clinical significance. Methods A total of 150 ICP patients hospitalized in our hospital from May 2012 to May 2015 were divided into two groups according to their gestational age. Among them, the patients diagnosed before 32 weeks were early-onset (group A) The patients diagnosed after 32 weeks were late-onset (group B). The differences between the two groups were retrospectively analyzed in terms of age, diagnosis gestational age, gestational gestational age, diagnosis to interparty period, birth weight, liver enzymes and coagulation indexes. Results There was a significant difference between the two groups in diagnosis and birth weight and birth weight (P <0.05). There was no significant difference in age, delivery gestational age, liver enzyme and coagulation index between the two groups (P> 0.05). The same birth gestational age, early-onset ICP pregnant women birth weight of newborns than late-onset ICP pregnant women give birth to newborns. Conclusions Early onset ICP diagnosed 32 weeks ago is associated with low birthweight at birth.