同种免疫需要协同刺激。大多数免疫反应的一个重要协同刺激旁路是通过抗原提呈细胞上的CD40和宿主T细胞上的CD154(4D40L)间的相互作用介导的。设想阻断协同刺激旁路,同时接触HLA不相容的白细胞可抑制同种免疫。研究设计与方法重型联合免疫缺陷小鼠(SCID),重建人的外周血淋巴细胞(Hu-PBL-SCID mice),这些淋巴细胞来自对HLA抗原的预处 Alloimmunization requires synergistic stimulation. An important costimulatory bypass for most immune responses is mediated through the interaction between CD40 on antigen presenting cells and CD154 (4D40L) on host T cells. It is hypothesized that blockade of costimulation by-pass, simultaneous exposure to HLA-incompatible leukocytes, may inhibit alloimmunization. Study Design and Methods Heavy combined immunodeficient mice (SCID), human peripheral blood lymphocytes (Hu-PBL-SCID mice) were reconstructed from pre-treatment of HLA antigens