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目的:分析长期住院的慢性精神分裂症患者代谢功能异常(代谢综合征)的相关影响因素,提供相应风险因素与预防措施。方法:对上海市长宁区精神卫生中心2011年3月至2012年3月精神科长期住院的精神分裂症患者测定其代谢指标,采用世界糖尿病联盟(IDF)全球统一标准定义代谢综合征,同时调查包括一般资料、康复方式、药物服用法、吸烟等风险因素,采用卡方检验、二元Logistic回归分析进行统计分析。结果:慢性长期住院患者代谢综合征的患病率为30.7%,不同抗精神病药品的代谢综合征发生率差异有统计学意义(χ2=24.56,P=0.001),男性、年龄、病程、吸烟、服药方式等是慢性精神分裂症患者代谢综合征患病的影响因素。结论:预防和管理慢性精神分裂症患者的代谢综合征有重要意义,针对慢性住院的精神分裂症患者的高危因素(如男性、长期住院、吸烟等),可以通过对其生活方式调整、加大与加强康复等措施进行干预。
Objective: To analyze the related factors of metabolic dysfunction (metabolic syndrome) in patients with chronic schizophrenia who have been hospitalized for a long time, and to provide the corresponding risk factors and preventive measures. Methods: Metabolic indexes were measured in long-term hospitalized patients with schizophrenia in psychiatric department from March 2011 to March 2012 in mental health center of Changning District, Shanghai. Metabolic syndrome was defined by the global standard of the World Federation of Diabetes (IDF) Including general information, rehabilitation methods, drug use, smoking and other risk factors, using the chi-square test, binary Logistic regression analysis for statistical analysis. Results: The prevalence of metabolic syndrome in chronic long-term hospitalized patients was 30.7%. The incidence of metabolic syndrome was significantly different among different antipsychotics (χ2 = 24.56, P = 0.001), male, age, duration, smoking, Medication and so on are the influencing factors of the metabolic syndrome in patients with chronic schizophrenia. Conclusion: It is of great importance to prevent and manage metabolic syndrome in patients with chronic schizophrenia. Risk factors (such as males, long-term hospitalizations, smoking, etc.) in schizophrenic patients with chronic inpatients can be adjusted by adjusting their life style. And strengthen the rehabilitation measures to intervene.