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目的观察乌司他汀在治疗百草枯中毒中的疗效。方法 50例百草枯中毒患者随机分为2组,对照组25例常规治疗,治疗组25例在常规治疗基础上应用乌司他汀。结果两组患者治疗后酶学指标和血肌酐明显下降。治疗组显著低于对照组。1周后治疗组的血氧分压明显高于对照组。结论早期应用乌司他汀可减轻百草枯对重要脏器的损害,减轻肺纤维化的发生。
Objective To observe the effect of ulinastatin in the treatment of paraquat poisoning. Methods 50 cases of paraquat poisoning were randomly divided into two groups, the control group of 25 cases of conventional treatment, the treatment group of 25 patients on the basis of routine treatment with ulinastatin. Results After treatment, the enzymological indexes and serum creatinine were significantly decreased in both groups. The treatment group was significantly lower than the control group. One week after the treatment group, the partial pressure of oxygen was significantly higher than that of the control group. Conclusion The early application of ulinastatin can reduce paraquat damage to important organs and reduce the incidence of pulmonary fibrosis.