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研究腺苷在利血平引起的大鼠行为性抑郁中的作用。应用Porsolt游泳试验 ,观察注射利血平引起的大鼠行为性抑郁 ,通过腹腔注射非特异性腺苷受体阻断剂咖啡因和特异性A1和A2腺苷受体阻断剂 ,确定腺苷在利血平诱导的大鼠行为性抑郁中的作用以及介导这种作用的受体。结果发现 :腹腔注射利血平 (4、6和 8mg/kg)可导致大鼠在游泳试验中漂浮时间明显延长 ,咖啡因和A2a腺苷受体阻断剂能明显缩短利血平导致的漂浮时间的延长。结论 :腺苷通过A2a受体介导利血平引起的大鼠的行为性抑郁。
To study the role of adenosine in reserpine-induced behavioral depression in rats. Porsolt swimming test was used to observe behavioral depression caused by injection of reserpine in rats. Intravenous injection of non-specific adenosine receptor blockers caffeine and specific A1 and A2 adenosine receptor blockers identified adenosine in Reserpine-induced behavioral depression in rats and the receptor that mediates this effect. The results showed that: intraperitoneal injection of reserpine (4, 6 and 8mg / kg) can lead to significantly prolonged floating time in swimming test, caffeine and A2a adenosine receptor blocker can significantly reduce reserpine-induced floating The extension of time. Conclusions: Adenosine induces behavioral depression in rats induced by reserpine through the A2a receptor.