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奎尼丁治疗是获得性QT间期延长综合征和尖端扭转型室性心动过速(Torsade de Pointes,尖端扭转型室速)的主要原因之一.作者分析了奎尼丁治疗期间QT间期延长(≥600msec)的24例(男8、女16)患者心电图和临床特征,其中20例伴有尖端扭转型室速(停用奎尼丁后自行终止).凡U波高于T波者,QT间期包括U波.本组内高血压性心脏病11例,心脏瓣膜病4例,心肌病4例,缺血性心脏病1例,用药前原有QT间期延长(分别为520、560msec)2例,特发性心律失常和快搏-慢搏综合征各1例.20例尖端扭转型室速中,有19例曾经直流电击证明其存在和复律成
The quinidine treatment is one of the major causes of acquired QT prolongation syndrome and Torsade de Pointes (torsades de pointes). The authors analyzed the QT interval (ECG) and clinical features of 24 patients (male 8, female 16) prolonged (≥600msec), of which 20 were accompanied by torsades de pointes ventricular tachycardia (self-termination after stopping quinidine) QT interval including U wave.In this group, 11 cases of hypertensive heart disease, valvular heart disease in 4 cases, 4 cases of cardiomyopathy, ischemic heart disease in 1 case, before treatment, the original QT interval was extended (520,560 msec ), 2 cases, idiopathic arrhythmia and fast pacing-slow stroke syndrome in 1 case.Among the 20 cases of Torsades de Pointes, 19 cases had DC shock to prove its existence and cardioversion