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为探索预测鼻内翻性乳头状瘤（NIP）癌变的可能性，采用免疫组化ABC法及胶银染色技术分别对20例NIP共24份标本进行CEA及AgNOR检测，以16例鼻息肉及18例界窦鳞癌为对照组。结果在20例NIP中有4例NIP术后切除大标本局部癌变，而术前标本示不典型增生。在此8价标本中（术前4份，术后4份），CEA全部呈浆膜型阳性，与鼻窦鳞癌CEA表达类型一致。AgNOR计数，术前标本与术后癌变标本其AgNOR颗粒分别为5．83个与8．86个，两者有显著差异，且术前标本AgNOR计数与其它3例不典型增生NIP均属同一组。结论，CEA在NIP中表达的类型在预测NIP癌变的临床应用上比AgNOR计数更有价值。
In order to explore the possibility of predicting the carcinogenesis of nasal inverted papilloma (NIP), CEA and AgNOR were detected in 24 specimens of 20 cases of NIP by immunohistochemical ABC method and silver colloidal silver staining respectively. 16 cases of nasal polyps 18 cases of sinus squamous cell carcinoma as a control group. Results In 20 cases of NIP, there were 4 cases of large local canceration resected after NIP, while preoperative specimens showed atypical hyperplasia. In this 8-price specimens (4 preoperative and 4 postoperative), CEA was all serosal positive and consistent with the CEA expression pattern of squamous cell carcinoma of the paranasal sinuses. AgNOR counts, preoperative specimens and postoperative cancerous specimens of AgNOR particles were 5.83 and 8.86, the two were significantly different, and preoperative specimens AgNOR count and other three cases of atypical hyperplasia NIP are the same group . In conclusion, the type of CEA expressed in the NIP is more valuable than the AgNOR count in predicting the clinical utility of NIP carcinogenesis.