论文部分内容阅读
目的建立与临床动脉瘤更加相似的动脉瘤动物模型。方法利用手术吻合法将15只大白兔制成15个顶端动脉瘤模型。制作后当日及2周后行形态、病理和行为表现的观察。采用自行设计循环加压装置,显微镜下使用高速摄影机记录试件整体形态的变化。通过图形分析软件测量试件变化值。结果共制作顶端动脉瘤模型15个,1个术后24h破裂,1个2周后破裂。动脉瘤模型建立后的平均直径为(2.10±0.24)mm(n=15),2周后动脉瘤平均直径为(3.25±0.54)mm(n=13),两者差异有统计学意义(P<0.05)。2周后病理检查可见瘤壁弹力层和胶原纤维明显减少或消失。得出试件的材料常数x1,x2均值分别为4.25602、113.0667和655.1316,0.2566292。构建出动脉瘤壁的本构方程σ=x1x2λ2Eexp[E2-E2)]。结论经酶处理的动脉瘤动物模型形态和病理上与临床动脉瘤更加相似。
Objective To establish an aneurysm animal model that is more similar to clinical aneurysms. Methods Fifteen rabbits were made into 15 apical aneurysms using surgical anastomosis. Morphological, pathological and behavioral findings were observed on the day after and 2 weeks after the procedure. Using self-designed circulating pressure device, microscope using high-speed camera to record the overall shape of the specimen changes. Change the value of the specimen through the graphic analysis software. Results A total of 15 apical aneurysm models were made. One was ruptured 24h after operation and one was ruptured after two weeks. The average diameter of the aneurysm model was (2.10 ± 0.24) mm (n = 15) and the average diameter of the aneurysm was (3.25 ± 0.54) mm (n = 13) after 2 weeks, the difference was statistically significant <0.05). Two weeks later, the pathological examination showed that the elastic layer and collagen fibers in the tumor wall significantly decreased or disappeared. Obtained the specimen material constant x1, x2 mean value were 4.25602,113.0667 and 655.1316,0.2566292. Construct the constitutive equation of aneurysm wall σ = x1x2λ2Eexp [E2-E2]]. Conclusions The enzymatic-treated aneurysm animal model is more similar in morphology and pathology to clinical aneurysms.