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日本Nagoya大学医院进行了100例柯兴氏病的手术,发现93例为垂体肿瘤并作了切除,术后症状完全缓解。Guiat和Hardy改良经蝶窦显微手术的普及,垂体激素放射免疫学及CT放射学检查等的进步,对于垂体腺瘤诊断和治疗已有明显的进展。但是直径5mm以下的微小腺瘤,蝶鞍和垂体的改变,即使应用现代放射学技术也很难被发现,因此对怀疑柯兴氏病和一些不能解决的问题依然存在。柯兴氏病临床症状如满月脸、水牛背、中心性肥胖、红脸、紫纹、多毛症、痤疮、肌无力、色素沉着、精神萎糜不振、侏儒症、高血压、糖尿病、月经不调见于许多病例。在一般情况下,与异位产生促肾上腺激素瘤相比较,这些症状的发生和进展是慢的。血浆ACTH和Cortisol基本值在柯兴氏病是升高
The 100 cases of Cushing’s disease were performed at the Nagoya University Hospital in Japan. Ninety-three cases were pituitary tumors and were resected. The symptoms were completely relieved after surgery. Guiat and Hardy improved the popularity of transsphenoidal sinus microsurgery, pituitary hormone radioimmunoassay, and CT radiography for advancement in the diagnosis and treatment of pituitary adenomas. However, in the case of tiny adenomas with a diameter of 5 mm or less, the changes in the sella and the pituitary gland are difficult to detect even with modern radiological techniques. Therefore, there are still some unresolved issues for Cushing’s disease. Clinical symptoms of Cushing’s disease such as full moon face, buffalo back, central obesity, red face, purple lines, hirsutism, acne, muscle weakness, hyperpigmentation, apathy, dwarfism, hypertension, diabetes, irregular menstruation Many cases. In general, the occurrence and progression of these symptoms are slow compared to ectopic production of adrenocortical tumors. Plasma ACTH and Cortisol values are elevated in Cushing’s disease