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应用化疗药物以治疗全身性恶性疾病,常伴有不同的毒性付作用,包括口腔炎和口腔溃疡。很多药物都会产生这些付反应,其中应用氟尿嘧啶(5FU)后,有75％病员发生口腔损害。已知机制之一,即这些抗肿瘤药物能通过干扰脱氧核糖核酸(nNA)的合成,迅速作用于正常和肿瘤组织的增殖细胞。口腔粘膜上皮具有高速度的DNA合成,大约5天为一个周期。因此,抑制DNA的产生也可破坏粘膜上皮细胞正常的复制和再生;最后随着口腔粘膜溃疡而发生萎缩。这种现象已在动物模型上使用氨甲喋呤(MTX)和
The use of chemotherapeutic drugs to treat systemic malignancies is often accompanied by different toxicities, including stomatitis and mouth ulcers. Many drugs produce these side effects. Among them, 75% of patients have oral lesions after applying fluorouracil (5FU). One of the known mechanisms is that these antitumor drugs can rapidly act on proliferating cells of normal and tumor tissues by interfering with the synthesis of deoxyribonucleic acid (nNA). The oral mucosal epithelium has high-speed DNA synthesis and is a cycle of approximately 5 days. Therefore, inhibiting the production of DNA can also disrupt the normal replication and regeneration of epithelial cells of the mucous membrane; finally, it atrophy with the ulceration of the oral mucosa. This phenomenon has been used on animal models with methotrexate (MTX) and