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目的:探讨中老年患者消化性溃疡复发的相关因素,为临床防治中老年患者消化性溃疡复发提供理论依据。方法:回顾性分析2013年6月至2015年6月我院收治的中老年消化性溃疡患者148例的临床资料,将随访过程中复发的25例患者分为复发组,未复发的123例患者分为未复发组,比较两组的临床资料,并通过多因素Logistic回归分析探讨中老年患者消化性溃疡复发的危险因素。结果:复发组患者的吸烟和服用糖皮质激素的比例、溃疡长径、最后一次随访幽门螺旋杆菌(HP)阳性率均明显高于未复发组(均P<0.05);多因素Logistic回归分析结果显示,吸烟、服用糖皮质激素、溃疡长径大、最后一次随访HP阳性为中老年患者消耗性溃疡复发的独立危险因素(均P<0.05)。结论:中老年患者消化性溃疡的复发与多种因素相关,临床医生应根据患者存在的危险因素,制定针对性的干预措施,以降低消化性溃疡的复发率。
Objective: To explore the related factors of peptic ulcer recurrence in middle-aged and elderly patients, and to provide a theoretical basis for prevention and treatment of peptic ulcer recurrence in middle-aged and elderly patients. Methods: The clinical data of 148 patients with peptic ulcer in middle-aged and elderly patients who were admitted to our hospital from June 2013 to June 2015 were analyzed retrospectively. Twenty-five patients who relapsed during follow-up were divided into recurrence group, 123 patients without recurrence The patients were divided into non-relapse group and clinical data of two groups. Logistic regression analysis was used to explore the risk factors of peptic ulcer recurrence in middle-aged and elderly patients. Results: The prevalence of smoking and taking glucocorticoid, the long diameter of ulcer and the last follow-up of Helicobacter pylori were significantly higher in relapse group than in non-recurrence group (all P <0.05). The multivariate Logistic regression analysis Showed that smoking, glucocorticoid, long diameter of ulcer, the last follow-up of HP positive were the independent risk factors of recurrence of peptic ulcer in middle-aged and elderly patients (all P <0.05). Conclusion: Relapse of peptic ulcer in middle-aged and elderly patients is related to many factors. Clinicians should make targeted interventions to reduce the recurrence rate of peptic ulcer according to the risk factors of patients.