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目的探讨复发性外阴阴道假丝酵母菌病(RVVC)真菌及合并其他病原体感染情况,为有效治疗提供依据。方法对性病门诊120例RVVC患者和120例同期在本院做健康查体妇女(对照组)行病原学检查及酵母菌培养鉴定。结果 120例RVVC患者阴道分泌物分离出124株假丝酵母菌,其中白假丝酵母菌85株(68.55%),非白假丝酵母菌39株(31.45%),对两性霉素B,5-氟胞嘧啶,制霉菌素及咪康唑具有较高的体外抗菌活性,敏感率分别为98.39%,95.97%,91.94%和90.32%;支原体感染63例(52.50%),衣原体感染20例(16.67%),其他病原体感染37例(30.83%)。对照组120例仅查出白假丝酵母菌7例,支原体感染14例,未查见衣原体,其他病原体感染4例。结论 RVVC的主要病原菌仍是白假丝酵母菌,制霉菌素、咪康唑仍可作为经验用药的首选药物;RVVC常合并支原体、衣原体感染,对久治不愈的RVVC患者,需注意是否合并有其他病原体感染,应予积极治疗。
Objective To investigate the infection of recurrent vulvovaginal candidiasis (RVVC) fungi and other pathogens, and provide a basis for effective treatment. Methods One hundred and twenty RVVC patients in STD clinic and 120 healthy volunteers in our hospital during the same period (control group) were enrolled in the etiological examination and yeast culture identification. Results A total of 124 Candida were isolated from vaginal secretions of 120 patients with RVVC, including 85 (68.55%) Candida albicans and 39 (31.45%) Candida albicans, - flucytosine, nystatin and miconazole have high in vitro antibacterial activity with sensitivity rates of 98.39%, 95.97%, 91.94% and 90.32% respectively; 63 cases (52.50%) of mycoplasma infection and 20 cases of chlamydial infection 16.67%), other pathogens in 37 cases (30.83%). In the control group, only Candida albicans was detected in 120 cases, mycoplasma infection was found in 14 cases, Chlamydia was not found, and other pathogens were infected in 4 cases. Conclusion RVVC is still the main pathogen of Candida albicans, nystatin, miconazole can still be used as the preferred drug of experience medication; RVVC often associated with mycoplasma, chlamydia infection, long-term treatment of RVVC patients, should pay attention to whether there are other pathogens Infection, should be actively treated.