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目的:探讨当归水溶性低分子质量部分抗炎作用的研究。方法:首先取80只SD大鼠随机分为空白对照组、模型组、氢化可的松2 mg·kg-1组和当归水溶性低分子质量部分0.18 g·kg-1、0.09 g·kg-1组。按1 mg·kg-1脂多糖(LPS)腹腔注射制作炎症模型,ELISA测定血浆肿瘤坏死因子(TNF-α)、白细胞介素(IL-6),比较各组给药前后TNF-α和IL-6的差异。然后取40只KM小鼠随机分为4组进行二甲苯致小白鼠耳肿胀试验,比较各组耳肿胀度。结果:与模型组比较,当归水溶性低分子质量部分组TNF-α、IL-6水平明显降低(P<0.05);当归水溶性低分子质量部分可明显抑制二甲苯致小白鼠耳肿胀(P<0.01)。结论:当归水溶性低分子质量部分具有明显的抗炎作用。
Objective: To investigate the anti-inflammatory effect of Angelica sinensis water-soluble low molecular weight fraction. Methods: Eighty SD rats were randomly divided into blank control group, model group, hydrocortisone 2 mg · kg -1 group and water soluble low molecular weight fraction of Angelica sinensis 0.18 g · kg -1, 1.09 g · kg- Group 1. The model of inflammation was established by intraperitoneal injection of 1 mg · kg-1 lipopolysaccharide (LPS), the levels of tumor necrosis factor (TNF-α) and interleukin (IL-6) were measured by ELISA. -6 differences. Then 40 KM mice were randomly divided into 4 groups xylene-induced ear swelling mice, ear swelling in each group were compared. Results: Compared with the model group, the levels of TNF-α and IL-6 in the water-soluble low molecular weight fraction of Angelica sinensis decreased significantly (P <0.05). The water-soluble low molecular weight fraction of Angelica sinensis <0.01). Conclusion: Angelica sinensis water-soluble low molecular weight part has obvious anti-inflammatory effect.