论文部分内容阅读
目的探讨心率变异性与高血压患者靶器官损害的相关性。方法分别检测高血压伴靶器官损害患者(实验组75例)、高血压患者不伴靶器官损害患者(对照组40例)24h动态心电图(SDNN、SDANN、LF、HF)、心脏彩超(LVM、LVMI)、颈动脉彩超、血生化、24h尿蛋白定量等指标。结果实验组SDNN、SDANN、RMSSD、HF低于对照组,实组组LF高于对照组,两组比较差异有统计学意义(P<0.05)。实验组75例中左室肥厚者35例,对照组75例有10例左室肥厚。实验组颈动脉壁增厚率73.33%,对照组为10.67%。两组相比有统计学意义(P<0.01)。实验组24h尿蛋白定量与对照组相比有统计学意义(P<0.01)。实验组与对照组血糖相比无统计学意义(P>0.05),肌酐、TC、TG、LDL-C两组相比有统计学意义(P<0.05)。结论高血压患者HRV程度与其靶器官功能损害程度有密切关系,定期观察高血压患者HRV与血压变化情况,并积极改善自主神经功能,对防治靶器官损害十分必要。
Objective To investigate the relationship between heart rate variability and target organ damage in patients with hypertension. Methods The levels of SDHN, SDANN, LF, HF and LVM in patients with hypertension without target organ damage (control group, 40 cases) LVMI), carotid ultrasound, blood biochemistry, 24h urinary protein and other indicators. Results The SDNN, SDANN, RMSSD and HF in the experimental group were lower than those in the control group. The LF in the real group was higher than that in the control group. There was significant difference between the two groups (P <0.05). 35 cases of left ventricular hypertrophy in 75 cases of experimental group, 75 cases of control group had 10 cases of left ventricular hypertrophy. The experimental group carotid artery wall thickening rate was 73.33%, the control group was 10.67%. The two groups were statistically significant (P <0.01). The urinary protein excretion in experimental group was significantly higher than that in control group (P <0.01). There was no significant difference between the experimental group and the control group (P> 0.05). The levels of creatinine, TC, TG and LDL-C in the two groups were statistically significant (P <0.05). Conclusions There is a close relationship between HRV and the degree of target organ dysfunction in hypertensive patients. It is necessary to observe the change of HRV and blood pressure in hypertensive patients regularly and to improve autonomic nervous function.