The Internet Accessible Mathematical Computation (IAMC) framework aims to make it easy to supply mathematical computing powers over the Internet/Web. The protocol-based IAMC framework enables developers to create interoperable clients and servers easily and independently. Presented are conceptual and experimental work on the IAMC framework architecture and major components: the Mathematical Computation Protocol (MCP), a client prototype (Dragonfly), a server prototype (Starfish), a mathematical encoding converter (XMEC), and an open mathematical compute engine interface (OMEI).