目的:探讨经单鼻孔-蝶窦入路垂体瘤切除手术的效果。方法:应用单鼻孔-蝶窦入路切除22例垂体瘤患者。结果:22例患者手术均顺利进行并于术后3月均获随访,全切除14例,次全切除5例,部分切除3例。结论:经单鼻孔-蝶窦入路显微切除垂体瘤属于微侵袭及功能保护性手术,符合现代神经外科的发展方向,严格把握适应症及禁忌症,完善手术技巧是提高手术效果的关键。 Objective: To investigate the effect of single nostril-sphenoid sinus pituitary tumor resection. Methods: Twenty-two cases of pituitary adenoma were excised by single nostril-sphenoid sinus approach. Results: Twenty-two patients were successfully performed and were followed up 3 months after operation. Total resection was performed in 14 cases, subtotal resection in 5 cases and partial resection in 3 cases. Conclusions: Microsurgery of pituitary tumor via single nostril - sphenoid sinus approach is a microinvasive and functional protective surgery, which is in line with the development of modern neurosurgery. Strict indications and contraindications and improvement of surgical techniques are the keys to improve the surgical outcome.