论文部分内容阅读
美国每年有15万多人患结直肠癌,25％的此病患者在初诊时就已有转移,50％的人死于转移癌,化疗和辅助治疗能延缓肿瘤的复发,可以治疗晚期(Duke D期)患者,还可减轻症状。70年代,出现卡介苗、左旋咪唑加5-FU的治疗方案。Moertel等人对1000例患者(43％已有淋巴结转移)使用5-FU,剂量为每天450mg/m~2连用5天后,每周口服左旋咪唑50mg/m~2,每天3次,口服1～3天,隔一周一次,共服1年。经观察发现,生存率63％,而未治疗组为47％。1990年美国卫生部把这一方案推荐给结直肠癌Duke C期的患者进行治疗。1993年美国乳腺和肛肠肿瘤
In the United States, more than 150,000 people have colorectal cancer each year. 25% of the patients have metastasized at the time of initial diagnosis. 50% of them have died of metastatic cancer. Chemotherapy and adjuvant therapy can delay the recurrence of cancer and can treat advanced disease. (Duke D) patients can also reduce symptoms. In the 1970s, treatment programs for BCG, levamisole plus 5-FU appeared. Moertel et al. used 5-FU in 1000 patients (43% had lymph node metastasis) at a daily dose of 450 mg/m 2 for 5 days, and then took oral levamisole 50 mg/m 2 twice a day, 3 times a day, and orally 1～ 3 days, once every other week, for a total of 1 year. It was observed that the survival rate was 63%, compared with 47% in the untreated group. In 1990, the U.S. Department of Health recommended this program to patients with Duke C colorectal cancer for treatment. American Breast and Anorectal Tumors in 1993