甲胎蛋白(AFP)是胎儿肝脏和卵黄囊合成的一种糖蛋白。在胎儿有神经管缺陷、先天性肾病、死胎等情况下,羊水及母体血清中AFP浓度升高。原发性肝细胞癌和内胚窦瘤患者血清中AFP浓度也升高。测定羊水及/或血清中AFP含量,有助于上述先天性畸形的产前诊断和有关肿瘤的早期发现及其疗效观察。目前利用传统的多克隆抗体(PcAb)的放射免疫分析 Alpha-fetoprotein (AFP) is a glycoprotein synthesized by the fetal liver and yolk sac. In the fetus with neural tube defects, congenital kidney disease, stillbirth and other circumstances, amniotic fluid and maternal serum AFP concentration increased. AFP levels are also elevated in patients with primary hepatocellular carcinoma and endodermal sinus tumors. Determination of amniotic fluid and / or serum AFP content, contribute to the congenital malformations of prenatal diagnosis and early detection of tumors and its efficacy observed. Currently radioimmunoassay using conventional polyclonal antibodies (PcAb)