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目的探讨超声检测早孕期胎儿颈项透明层增厚筛查先天性心脏病(CHD)的诊断价值。方法选择2010年1月至2012年12月在四川大学华西第二医院就诊的中、低危妊娠孕妇,采用超声检测胎儿颈项透明层厚度(NT),结合胎儿超声心动图检查诊断胎儿先天性心脏病。结果 2 764例就诊孕妇中对2 443例孕妇进行了B超NT值检测(88.3%),最终纳入2 125例胎儿进行分析。B超筛查发现颈项透明层厚度>2.5 mm的胎儿68例(3.2%),产前诊断胎儿先天性心脏病11例(5.2/1 000),11例先天性心脏病胎儿中有5例颈项透明层增厚。胎儿颈项透明层增厚筛查先天性心脏病敏感度和特异度分别为45.5%和97.0%。结论胎儿颈项透明层增厚发生先天性心脏病风险增加,其可作为筛查先天性心脏病的辅助诊断方法。
Objective To investigate the value of ultrasonography in the diagnosis of congenital heart disease (CHD) thickened by the transparent layer of fetal neck in early pregnancy. Methods From January 2010 to December 2012 at the second West China Hospital of Sichuan University for treatment of pregnant women, low-risk pregnant women, the ultrasound detection of fetal neck transparent layer thickness (NT), combined with fetal echocardiography to diagnose fetal congenital heart disease. Results A total of 2 443 pregnant women in 2 764 pregnant women underwent B-NT examination (88.3%) and eventually included 2 125 fetuses for analysis. B-ultrasound screening revealed 68 (3.2%) fetuses with a clear neck> 2.5 mm in thickness, prenatal diagnosis of fetal congenital heart disease in 11 (5.2 / 1,000), and 11 of 11 congenital heart disease fetuses Thick transparent layer. The sensitivities and specificities of congenital heart disease were 45.5% and 97.0% for fetal neck transparent layer thickening screening respectively. Conclusion There is an increased risk of congenital heart disease in the thickening of the transparent layer of the fetal neck, which can be used as a diagnostic method for screening congenital heart disease.