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成人急性淋巴细胞白血病(ALL)43例。男24例,女19例,年龄15—79岁(中位年龄41岁)。37例检查了淋巴细胞表面标记,其中null-ALL33例,B-ALL 2例,T-ALL 2例。诱导缓解用V(V′)P疗法[长春新硷、(Vindesine)、强的松龙]3个疗程后,对完全缓解者进行巩固化疗,对部分缓解或无效者用DV(V′)MP[柔红霉素,长春新硷、(Vindesine)、6-MP、强的松龙]原则上进行2个疗程,然后对仍未缓解病例进一步进行V(V′)AP疗法[长春新碱、(Vindesine)、L-天门冬酰胺酶(ASP)、强的松龙] 1个疗程。另外,对完全缓解的病例,用MTX,强的松龙或者阿糖胞苷中的两种或3种行鞘内注射。维持强化疗法用MTX6-MP、环磷酰胺三种药交替疗法或DVMP疗法和MTX静注交替疗法或MTX、6-MP并用和DV
Adult acute lymphoblastic leukemia (ALL) 43 cases. There were 24 males and 19 females, aged 15-79 years (median age 41 years). Lymphocytic surface markers were examined in 37 patients, including 33 cases of null-ALL, 2 cases of B-ALL, and 2 cases of T-ALL. After the three courses of induction of remission with V(V’)P therapy [Changchun Xinmin, (Vindesine), Prednisolone], chemotherapy for complete remission was performed, and DV(V’)MP was used for partially relieved or ineffective patients. [Daurobomycin, Changchun Xinxie, (Vindesine), 6-MP, Prednisolone] In principle, two courses of treatment are performed, and then V(V’)AP therapy is further performed on the unremitted cases. [Vincristine, (Vindesine), L-asparaginase (ASP), Prednisolone] 1 course of treatment. In addition, in case of complete remission, two or three of MTX, prednisolone or cytarabine were intrathecally injected. Maintenance intensive therapy with MTX6-MP, cyclophosphamide, or DVMP and MTX intravenous or MTX, 6-MP, and DV