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目的:探讨鼻、喉部神经内分泌癌的临床病理特点、治疗方法及疗效。方法:回顾性分析6例鼻、喉部神经内分泌癌患者的临床资料。采用单纯放疗1例,以手术为主的综合治疗5例。结果:全部患者随访11～84个月;2例术后复发,2例术后出现颈淋巴结转移,其中1例行颈淋巴结清扫术,1例无手术指征而行放、化疗。3例出现局部复发、颈部淋巴结肿大、肝或肺转移。至末次随访,4例死亡,2例无瘤生存。结论:鼻、喉部神经内分泌癌是一组形态、预后各异的病变,正确诊断有赖于临床特点、电镜、免疫组织化学检查结果。CT及MRI检查有助了解病变的范围及性质。不同病理类型神经内分泌癌的治疗方法及预后不同,宜采用以手术为主的综合治疗。
Objective: To investigate the clinicopathological features, treatment and efficacy of nasal and laryngeal neuroendocrine carcinoma. Methods: The clinical data of 6 patients with neuroendocrine carcinoma of the nose and throat were retrospectively analyzed. One case was treated with radiotherapy alone, and 5 cases were treated by surgery. Results: All patients were followed up for 11-84 months. Two patients relapsed after operation. Two patients had cervical lymph node metastasis after surgery. One patient underwent neck dissection and one patient underwent radiotherapy and chemotherapy without operation indications. 3 cases of local recurrence, cervical lymph node enlargement, liver or lung metastasis. Until the last follow-up, 4 patients died and 2 patients survived without disease. Conclusion: Nasal and laryngeal neuroendocrine carcinoma is a group of morphological and prognostic lesions, the correct diagnosis depends on clinical features, electron microscopy, immunohistochemical findings. CT and MRI can help to understand the extent and nature of the lesion. Different pathological types of neuroendocrine cancer treatment and prognosis is different, should be used to surgery-based comprehensive treatment.