据《丁香园》9月26日消息报道,许多肿瘤的基因组异常复杂,存在代偿性耐药机制,都可能导致靶向治疗失败。大多数肿瘤不象慢性粒细胞白血病(CML)那样简单,抑制单一信号途径难以长期控制疾病。对驱动突变了解越多,就越意识到罕见肿瘤信号途径实际上很常见,存在一系列所谓的 According to “Clove Park” September 26 news reports, many of the tumor’s genome is extremely complex, there are compensatory mechanisms of resistance, may lead to the failure of targeted therapies. Most tumors are not as simple as chronic myeloid leukemia (CML) and inhibiting a single signaling pathway makes it difficult to control the disease over the long term. The more you know about drive mutations, the more aware that rare tumor signaling pathways are actually common, with a series of so-called