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目的探讨T2DM患者斋月前后体内氧化应激的变化及其影响因素。方法选择穆斯林教T2DM患者68例,分为斋戒组和对照组。测定斋月前后FPG、2hPG、HbA1c、TC、TG、HDL-C、LDL-C和丙二醛(MDA)、超氧化物歧化酶(T-SOD)、总抗氧化力(T-AOC)、谷胱甘肽过氧化物酶(GSH-Px)等氧化应激指标,分析氧化应激变化的影响因素。结果斋戒组斋月前后FPG、2hPG、HbA1c、TC、TG、LDL-C、MDA较对照组增高,HDL-C、T-SOD、T-AOC、GSH-Px较对照组降低(P<0.05)。Lo-gistic逐步回归分析显示,斋月后MDA升高和T-SOD、T-AOC、GSH-Px降低与血糖增高(HbA1c≥7.0%)及LDL-C异常有关。结论 T2DM患者斋月前后MDA升高同时抗氧化应激水平降低,且可能与血糖、血脂控制不良有关。
Objective To investigate the changes of oxidative stress in vivo and its influencing factors before and after Ramadan in T2DM patients. Methods Sixty-eight Muslim patients with T2DM were selected and divided into fasting group and control group. The contents of FPG, 2hPG, HbA1c, TC, TG, HDL-C, LDL-C and MDA, T-SOD, T-AOC, (GSH-Px) and other oxidative stress indicators, the impact of oxidative stress changes. Results Fasting FPG, 2hPG, HbA1c, TC, TG, LDL-C and MDA in fasting group were higher than those in control group and HDL-C, T-SOD, T-AOC and GSH-Px were lower than those in control group (P <0.05). Lo-gistic stepwise regression analysis showed that the increase of MDA and the decrease of T-SOD, T-AOC and GSH-Px after Ramadan were related to the increase of blood glucose (HbA1c≥7.0%) and the abnormality of LDL-C. Conclusions The level of MDA and the level of antioxidant stress in T2DM patients before and after Ramadan decrease, which may be related to the poor control of blood glucose and blood lipids.