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目的 探讨支气管动脉灌注化疗 (BAI)联合经皮肺穿碘油标记无水乙醇混悬液瘤内注射 (PAI)治疗晚期肺癌的临床价值。方法 对经细胞学证实的 13例肺癌及 5例肝癌双肺多发转移患者共 32只病灶 ,在电视或CT引导下施行了 5 2次BAI联合 78次PAI治疗 ,其中 1例治疗后行手术肿块切除 ,对其标本进行了病理组织学研究。结果 标本病理表现为肿瘤大面积坏死 ;治疗总有效率为 83.8% ;其 6、12、18个月生存率分别为 10 0 %、77.7%、6 1%。结论 BAI联合PAI这一双介入疗法既能治疗原发灶 ,又可控制转移灶 ,且对较大肺癌也取得了较好的疗效叠加作用 ,是一种较好的综合性治疗方案。
Objective To investigate the clinical value of bronchial arterial infusion chemotherapy (BAI) combined with percutaneous pulmonary perfusion with labeled ethanol suspension (PAI) in the treatment of advanced lung cancer. Methods Twenty-two lesions of 13 patients with lung cancer and 5 patients with metastatic lung cancer with multiple cytology confirmed by cytology were treated with BAI combined with 78 PAIs under the guidance of TV or CT. Among them, 1 patient underwent surgical resection Excision, the specimens were histopathologically studied. Results The pathological findings of the specimens were gross tumor necrosis. The total effective rate was 83.8%. The 6, 12 and 18-month survival rates were 100%, 77.7% and 61% respectively. Conclusions BAI combined with PAI, a dual interventional therapy, can not only treat the primary tumor but also metastasis, and also achieve a better therapeutic effect for larger lung cancer. It is a good and comprehensive treatment plan.