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目的:探讨超声引导下射频消融治疗顽固性围绝经期功血的疗效及外周血性激素的变化。方法:应用超声引导下射频消融治疗47例顽固性围绝经期功血,并于术后3、6、12月追踪疗效及外周血性激素促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)。结果:47例患者经射频消融治疗后取得明显临床疗效,治愈率85.11%(40/47),好转率12.77%(6/47);无效率2.13%(1/47)。一次性治疗总有效率为97.88%,且射频消融治疗后,FSH、LH、E2均无明显改变。结论:射频消融治疗功血操作简单,创伤小,痛苦小,治愈率高,并发症少,费用低,不影响卵巢内分泌功能,是目前治疗顽固性围绝经期功血安全有效的微创方法之一。
Objective: To investigate the effect of ultrasound-guided radiofrequency catheter ablation on intractable perimenopausal dysfunctional uterine bleeding and the changes of peripheral blood hormones. Methods: Forty-seven cases of refractory peri-menopausal dysfunctional uterine bleeding were treated with radiofrequency ablation guided by ultrasound. The efficacy and the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) , Estradiol (E2). Results: 47 patients achieved significant clinical effect after radiofrequency ablation, the cure rate was 85.11% (40/47), the improvement rate was 12.77% (6/47); the inefficiency rate was 2.13% (1/47). The total effective rate of one-off treatment was 97.88%. After radiofrequency ablation, there was no significant change in FSH, LH and E2. Conclusion: Radiofrequency catheter ablation is a safe and effective minimally invasive method for the treatment of refractory perimenopausal dysfunctional uterine bleeding due to its simple operation, small trauma, little pain, high cure rate, few complications, low cost and no effect on ovarian endocrine function one.